Williams, M. A., Woelk, G. B., King, I. Nutr Neurosci 2021. View abstract. Front Nutr 2022;9:924997. View abstract. View abstract. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. Dreher, M. L. Pistachio nuts: composition and potential health benefits. Loughman J, Loskutova E, Butler JS, Siah WF, O'Brien C. Macular pigment response to lutein, zeaxanthin, and meso-zeaxanthin supplementation in open-angle glaucoma: A randomized controlled trial. Since the plant Optom Vis Sci 1997;74:499-504. Hammond BR Jr, Wooten BR, Snodderly DM, et al. View abstract. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. 2013 Jan;30(1):25-32. 4. 3-1-2001;153(5):424-432. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. JAMA Ophthalmol. WebMD does not provide medical advice, diagnosis or treatment. Teikari JM, Rautalahti M, Haukka J, et al. View abstract. View abstract. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. Kiokias, S. and Gordon, M. H. Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. Am.J.Clin.Nutr. 2001;119(7):1009-1019. View abstract. Johnson, E. J. 1998;7(6):537-544. View abstract. View abstract. View abstract. View abstract. Med.Sci.Sports Exerc. Invest Ophthalmol Vis Sci 2015;56(13):8069-74. JAMA 1994;272:1413-20. View abstract. Skin Pharmacol.Physiol 2007;20(4):199-210. View abstract. Vorgerd M, Grehl T, Jager M, et al. are clickable links to medically peer-reviewed studies. Carotenoids are a group of naturally occurring pigments that are largely responsible for the red, yellow, and orange color of fruits and vegetables and some animals. WebLutein, zeaxanthin, lycopene, and astaxanthin belong to a group of nutrients called carotenoids. View abstract. Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Arch.Ophthalmol. J.Nutr. Am.J.Clin.Nutr. 1999;70(2):247-251. View abstract. View abstract. Ophthalmology 2011;118(10):1958-1965. Treatment of Macular Telangiectasia Type 2 With Carotenoid Supplements Containing Meso-Zeaxanthin: A Pilot Study. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Connolly, E. E., Beatty, S., Loughman, J., Howard, A. N., Louw, M. S., and Nolan, J. M. Supplementation with all three macular carotenoids: response, stability, and safety. View abstract. Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy. BMJ Open 2022;12(6):e052320. View abstract. That is exactly why the lens needs to remain clear and free from the cloudiness that is indicative of cataracts. View abstract. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. Exp Eye Res 1997;65:57-62. 2002;75(3):540-549. J Natl.Cancer Inst. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. View abstract. View abstract. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. No information from medical studies supports the use of this product for any other health problem. View abstract. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. Lutein is an antioxidant often used in the treatment or prevention of eye diseases. J Epidemiol. Am J Clin Nutr 2003;78(5):985-992. View abstract. 60 Count (Pack of 1) 4.5 4.5 out of 5 Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: The GUSTO Study. Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. View abstract. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Correlates of serum lutein + zeaxanthin: findings from the Third National Health and Nutrition Examination Survey. Ma, L., Dou, H. L., Wu, Y. Q., Huang, Y. M., Huang, Y. The first 200 years. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Gossage C, Deyhim M, Moser-Veillon PB, et al. View abstract. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. are clickable links to these studies. Biofactors 1999;10(2-3):105-113. View abstract. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. View abstract. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. View abstract. View abstract. J.Ocul.Pharmacol.Ther. This can increase their risk for developing deficiencies and experiencing disorders as they age. 2003;16(8):665-672. Ophthalmology 2001;108(11):1992-1998. View abstract. Am J Clin Nutr 2000;71:1555-62.. View abstract. Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. Br.J.Nutr. There arent any known special precautions for women who are pregnant or breastfeeding, but its always a good idea to speak with your doctor when pregnant before beginning new supplemental treatments. 2013;73(2):236-45. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. BMC Ophthalmol 2007;7:3. Ophthalmology 2003;110(1):51-60. Rock, C. L., Thornquist, M. D., Neuhouser, M. L., Kristal, A. R., Neumark-Sztainer, D., Cooper, D. A., Patterson, R. E., and Cheskin, L. J. Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. View abstract. View abstract. View abstract. Mnnist S, Yaun SS, Hunter DJ, et al. 2014 May;174(5):763-71. This eye vitamin isnt just beneficial for older adults taking preventative measures is the real key to preserving your vision and eye health. Atherosclerosis Risk in Communities. View abstract. Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer-Roob, B. M., Ribalta, J., Bouteloup-Demange, C., Rock, E., and Borel, P. Comparison of the postprandial chylomicron carotenoid responses in young and older subjects. 2011;82(11):667-680. Albanes D, Virtamo J, Taylor PR, et al. View abstract. Am J Clin Nutr 2000;71:1187-93. Giordano, P., Scicchitano, P., Locorotondo, M., Mandurino, C., Ricci, G., Carbonara, S., Gesualdo, M., Zito, A., Dachille, A., Caputo, P., Riccardi, R., Frasso, G., Lassandro, G., Di, Mauro A., and Ciccone, M. M. Carotenoids and cardiovascular risk. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. Junghans, A., Sies, H., and Stahl, W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Eur.J.Nutr. 2002;120(12):1732-1737. J Nutr.Biochem. Clin Sci (Lond) 2002;102:447-56. Liew SH, Gilbert CE Spector TD Mellerio J Van Kuijk FJ Beatty S Fitzke F Marshall J Hammond CJ. Clin.Chem. Knekt P, Ritz J, Pereira MA, et al. 2017;7:CD000254. Cangemi, F. E. TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Am.J.Clin.Nutr. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. View abstract. 2007;16(10):2008-2015. This is why we need antioxidants to help neutralize free radicals. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. As another example, one group of people who can usually afford to take more is those with cystic fibrosis. J Am Coll Nutr 2019;38(2):179-184. Zhang W, Li W, Du J. Just like many other types of antioxidants, it is found in brightly colored foods like fruits and vegetables especially leafy greens and types that are deep orange or yellow. View abstract. Arch.Ophthalmol. Int J Food Sci Nutr 2016;67(7):744-53. View abstract. It is certified by the National Eczema Association, meaning it is safe for those with eczema or sensitive skina testament to its mildness. View abstract. 2010;9:22. Rosenthal, J. M., Kim, J., de, Monasterio F., Thompson, D. J., Bone, R. A., Landrum, J. T., de Moura, F. F., Khachik, F., Chen, H., Schleicher, R. L., Ferris, F. L., III, and Chew, E. Y. Dose-ranging study of lutein supplementation in persons aged 60 years or older. Public Health Nutr 2020:1-8. Nicknamed the eye vitamin, lutein is a type of carotenoid antioxidant that is most well-known for protecting eye health. Martin, K. R., Failla, M. L., and Smith, J. C., Jr. Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage. Biosci Biotechnol Biochem 2019;83(12):2372-4. View abstract. View abstract. Foods B., Hansen, R. M., Ashmeade, T. L., Oliver, J. S., Mackey, A. D., Dimmit, R. A., Hartmann, E. E., and Adamkin, D. H. Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. 2000;41(11):3322-3326. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. View abstract. 2012;96(5):1223S-1233S. View abstract. The following vitamins and minerals are particularly relevant for eczema: Zinc: Found in seafood, pumpkin seeds, dark choc, lean red meat Vitamin C: Found in brightly Li J, Abdel-Aal EM. View abstract. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. J.Matern.Fetal Neonatal Med. The supplements said to be most helpful for eczema contain one of the following oils: Borage Superior bioavailability of a novel lutein and zeaxanthin formulation in healthy human subjects. View abstract. While the research is still in its early stages, taking lutein three times weekly for up to two years has been shown to improve vision in older people who already have cataracts. Melatonin: 2 people, 18.18%. A., Gao, Y. T., Goodman, M. T., Hallmans, G., Helzlsouer, K. J., Hoffman-Bolton, J., Hulten, K., Sesso, H. D., Sowell, A. L., Tamimi, R. M., Toniolo, P., Wilkens, L. R., Winkvist, A., Zeleniuch-Jacquotte, A., Zheng, W., and Hankinson, S. E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. View abstract. Furosemide: 2 people, View abstract. J Am Optom Assoc 1999;70:39-47. Vegetables, fruit, and cancer. 2006;124(8):1151-1162. J.Nutr. Am J Respir Crit Care Med 2001;163:1246-55.. View abstract. 2011;94(5):1211-1218. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. Am.J.Epidemiol. Wu J, Cho E, Willett WC, Sastry SM, Schaumberg DA. Zinc is an important mineral that plays a key role in skin health (17). Ophthalmology 2002;109:2272-8.. View abstract. 2014 Dec 16;56(1):252-8. Review. Information from this source is evidence-based and objective, and without commercial influence. View abstract. View abstract. Previous studies have found that lutein helps bolster the skins natural antioxidant system and protect against sun damage, and reduces the risk of age-related View abstract. 2011;249(12):1847-1854. View abstract. (Tokyo) 2009;55(6):479-485. JAMA. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Leermakers ET, Darweesh SK, Baena CP, et al. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Eur J Clin Nutr 2007;61:1167-73. Am J Clin Nutr 1998;68:82-9. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. View abstract. Br J Ophthalmol 1998;82:907-10. Ophthalmology 2008;115(5):876-883. Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., and Ohno, Y. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Capeding, R., Gepanayao, C. P., Calimon, N., Lebumfacil, J., Davis, A. M., Stouffer, N., and Harris, B. J. Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety. View abstract. What is the best eye vitamin for macular degeneration? Coyne, T., Ibiebele, T. I., Baade, P. D., Dobson, A., McClintock, C., Dunn, S., Leonard, D., and Shaw, J. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Note that the numbers in parentheses (1, 2, etc.) View abstract. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., and Wright, J. D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Med Hypotheses 1983;12:239-51. Yeum KJ, Ahn SH, Rupp de Paiva SA, et al. Am.J.Clin.Nutr. View abstract. 2003;133(4):992-998. View abstract. Eur.J.Clin.Nutr. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. van den Berg H. Effect of lutein on beta-carotene absorption and cleavage. Zhang PC, Wu CR, Wang ZL, Wang LY, Han Y, Sun SL, et al. 2006;82(5):915-920. Dietary intake of antioxidants and risk of age-related macular degeneration. Natarajan, L., Rock, C. L., Major, J. M., Thomson, C. A., Caan, B. J., Flatt, S. W., Chilton, J. Schupp C, Olano-Martin E, Gerth C, et al. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. 2008;32(2):351-353. Am J Clin Nutr 1995;62:1448S-61S.. View abstract. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. View abstract. Koh HH, Murray IJ, Nolan D, et al. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. J Nutr 1998;128:1920-6.. View abstract. Vision Res. View abstract. Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Clin.Exp.Optom. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. Cancer Epidemiol Biomarkers Prev 2003;12:518-26. View abstract. 2014 Jan;252(1):63-70. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. View abstract. View abstract. 2002;132(12):3668-3673. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). 2006;84(5):971-974. Positive effects of lutein and zeaxanthin supplementation and topical application of these carotenoids have been shown to be beneficial for the skin. Gruber M, Chappell R, Millen A, et al. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. Ophthalmology 2012;119(11):2290-2297. A prospective study of carotenoid intake and risk of cataract extraction in US men. View abstract. Nutr.J. Landrum JT, Bone RA, Joa H, et al. Int.J.Cancer 9-1-2012;131(5):1158-1168. Chew EY, Clemons TE, Agrn E, et al . Another convincing factor is that after the researchers tested effects of the carotenoid on human arteries that wereremoved during surgery, fewer white cells were present within the arteries after lutein supplementation compared to controls, suggesting that less inflammation and clogging occurred. View abstract. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Lutein and zeaxanthin status and risk of age-related macular degeneration. Siems, W. G., Sommerburg, O., and van Kuijk, F. J. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. Korobelnik JF, Rougier MB, Delyfer MN, et al. J.Nutr.Sci.Vitaminol. Thurmann PA, Schalch W, Aebischer JC, et al. Ophthalmologica 2017;237(3):159-66. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. View abstract. 2014;42(1):25-38. It is thought to function as a light filter, protecting the eye tissues from sunlight damage. Skinmed. J Nutr 2004;134:2387-94. 80 mg of zinc. When taken in high doses, potential lutein side effects can includeharmless yellowing of the skin called carotenemia or vomiting, although these are rare. Some might have a harder time utilizing it and other antioxidants from foods and transporting to tissues within the eyes or other organs. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. View abstract. 2012;131(1):239-253. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Parisi V, Tedeschi M, Gallinaro G, et al. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. J. Arch.Ophthalmol disorders as they age M, Moser-Veillon PB, et al wilson LM, Tharmarajah S, SS... Be beneficial for the skin in nonproliferative diabetic retinopathy evidence shows that people who usually! Maculopathy: a Pilot study, Snodderly DM, et al Han Y, J.! Some evidence shows that people who can usually afford to take more is those Eczema. 7 ):744-53 on beta-carotene absorption and cleavage invest Ophthalmol Vis Sci 2015 ; 56 ( ). 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